Company Filing History:
Years Active: 1990-1991
Title: Walter J Doll: Innovator in Transdermal Drug Delivery
Introduction
Walter J Doll is a notable inventor based in Lexington, KY (US). He has made significant contributions to the field of transdermal drug delivery, with a focus on enhancing the absorption of drugs through the skin. His innovative work has led to the development of novel compounds that have practical applications in medicine.
Latest Patents
Walter J Doll holds 2 patents related to his research. His latest patents include the compound 3-hydroxy-N-methylpyrrolidone, which is recognized for its effectiveness as a transdermal enhancer for drug absorption in both humans and animals. The preparation of this compound involves a series of chemical reactions starting from delta-butyrolactone, which is converted into methyl 2,4-dibromobutyrate. This intermediate is then reacted with methylamine to form N-methyl-2,4-dibromobutyramide. Following this, the compound undergoes ring closure to produce 3-bromo-N-methyl-2-pyrrolidone, which is subsequently reacted with an alkaline earth metal carbonate or alkaline metal carbonate to yield 3-hydroxy-N-methyl-2-pyrrolidone.
Career Highlights
Walter J Doll is affiliated with the University of Kentucky Research Foundation, where he conducts his research and development activities. His work has been instrumental in advancing the understanding of transdermal drug delivery systems.
Collaborations
Some of his notable coworkers include George A Digenis and Amale Hawi, who have collaborated with him on various research projects.
Conclusion
Walter J Doll's contributions to the field of transdermal drug delivery through his innovative patents highlight his role as a significant inventor. His work continues to influence the development of effective drug delivery systems.