Company Filing History:
Years Active: 1997
Title: The Innovations of Tracy L Ripmaster
Introduction
Tracy L Ripmaster is a notable inventor based in Charlestown, MA (US). She has made significant contributions to the field of biochemistry, particularly in the development of human alanyl-tRNA synthetase proteins. Her work has implications for both diagnostics and therapeutic applications in autoimmune diseases.
Latest Patents
Tracy L Ripmaster holds a patent for "Human alanyl-tRNA synthetase proteins, nucleic acids and tester strains." This patent involves isolated, recombinant nucleic acids that encode alanyl-tRNA synthetase (AlaRS) of human origin. These constructs have been utilized to produce recombinant human AlaRS, which is crucial for the specific aminoacylation of tRNA by alanine. The recombinant enzyme has been purified and is recognized by antibodies produced by patients with antisynthetase syndrome. This syndrome involves the production of antibodies against the human alanyl-tRNA synthetase in their own cells. The isolated enzyme and specific antibodies can be instrumental in diagnosing and monitoring this disease. Additionally, the human alanyl-tRNA synthetase can serve as a target for antimicrobial agents, assessing their toxic effects in humans through various biochemical assays.
Career Highlights
Throughout her career, Tracy has worked with prominent organizations, including Cubist Pharmaceuticals and the Japanese Foundation for Cancer Research. Her experience in these institutions has allowed her to advance her research and contribute to significant scientific advancements.
Collaborations
Tracy has collaborated with esteemed colleagues such as Kiyotaka Shiba and Paul R Schimmel. These partnerships have further enriched her research and innovation in the field.
Conclusion
Tracy L Ripmaster's contributions to the field of biochemistry, particularly through her patent on human alanyl-tRNA synthetase, highlight her innovative spirit and dedication to advancing medical science. Her work not only aids in understanding autoimmune diseases but also paves the way for potential therapeutic solutions.
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