Nagoya, Japan

Tomoyuki Shirai


Average Co-Inventor Count = 3.0

ph-index = 1

Forward Citations = 3(Granted Patents)


Company Filing History:


Years Active: 2006

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1 patent (USPTO):Explore Patents

Title: Tomoyuki Shirai: Innovator in Prostate Cancer Research

Introduction

Tomoyuki Shirai is a prominent inventor based in Nagoya, Japan. He has made significant contributions to the field of medical research, particularly in the development of animal models for studying prostate cancer. His innovative work has the potential to advance our understanding of this disease and improve treatment options.

Latest Patents

Tomoyuki Shirai holds a patent for a model rat with the onset of prostatic cancer. This invention aims to provide a stable rat model that can develop prostate cancer, including invasive forms of the disease. The patent describes a method for creating this model by ligating an SV40 large T antigen gene onto the downstream of the rat probasin gene promoter. The resulting PBSVT transgene is introduced into a fertilized egg of a Sprague-Dawley rat, which is then transplanted into a recipient rat. The transgenic rat obtained is mated with a wild-type Sprague-Dawley rat, allowing for the breeding of transgenic offspring that can develop prostate cancer. This model can be bred for generations, enabling researchers to select transgenic rats through histopathological observation of the prostate.

Career Highlights

Tomoyuki Shirai is affiliated with the Japan Science and Technology Agency, where he continues to conduct research and develop innovative solutions in the field of cancer research. His work has garnered attention for its potential impact on understanding prostate cancer and developing new therapeutic strategies.

Collaborations

He has collaborated with notable colleagues, including Makoto Asamoto and Satoru Takahashi, to further advance research in this critical area of health.

Conclusion

Tomoyuki Shirai's contributions to the field of prostate cancer research through his innovative rat model highlight the importance of animal models in medical research. His work not only enhances our understanding of prostate cancer but also paves the way for future advancements in treatment.

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