Thomas P Jarvie

Title: Innovations of Thomas P. Jarvie

Introduction

Thomas P. Jarvie is a notable inventor based in Middletown, Connecticut. He has made significant contributions to the field of solid-state nuclear magnetic resonance (NMR) through his innovative methods for distance measurements. His work has implications for drug discovery and design, enhancing the understanding of pharmaceutical compounds.

Latest Patents

Jarvie holds a patent for a "Method for distance measurements with solid-state NMR." This invention encompasses various techniques for analyzing data generated by solid-state NMR experiments, including rotational echo double resonance (REDOR), transferred echo double resonance (TEDOR), dipolar recoupling at the magic angle (DRAMA), dipolar recoupling with a windowless sequence (DRAWS), and melding of spin-locking and DRAMA (MELODRAMA). The methods utilize a new analytical transform or the maximum entropy method, allowing for simultaneous and precise distance measurements, even from nuclei with identical chemical shifts. This advancement provides high-quality distance measurements from disordered solid-state materials, significantly improving drug discovery and design.

Career Highlights

Jarvie is associated with Curagen Corporation, where he applies his expertise in NMR technology. His work has been instrumental in advancing the methodologies used in the analysis of pharmaceutical compounds.

Collaborations

He has collaborated with notable colleagues, including Joel S. Bader and Gregory T. Went, contributing to the innovative research environment at Curagen Corporation.

Conclusion

Thomas P. Jarvie's contributions to solid-state NMR and his innovative patent have made a significant impact on the field of drug discovery. His work continues to influence the methodologies used in pharmaceutical research and development.