Company Filing History:
Years Active: 2006
Title: Thomas Holtschke: Innovator in Gene Expression Optimization
Introduction
Thomas Holtschke is a notable inventor based in Munich, Germany. He has made significant contributions to the field of gene expression optimization, particularly in eukaryotic cells. His innovative work has led to the development of a patented process that enhances gene expression through advanced techniques.
Latest Patents
Holtschke holds a patent for the "Optimization of cells for endogenous gene activation." This invention focuses on a process for optimizing gene expression in cells. It involves changing the expression of a nucleic acid sequence present endogenously in a eukaryotic cell by introducing a heterologous expression control sequence into the genome. The process utilizes homologous recombination and site-specific recombinase-mediated excision of inserted foreign DNA, allowing for the replacement with additional heterologous expression control sequences or amplification genes. Furthermore, the invention includes methods for introducing nucleic acid sequences that bind to activator proteins, such as hypoxia-inducible factors, into the genome to modify target gene expression. Additionally, it provides a process for testing the influence of non-coding nucleic acid fragments on target gene expression by determining the expression of a reporter gene.
Career Highlights
Holtschke is currently employed at Roche Diagnostics GmbH, where he continues to advance his research in gene expression and cellular optimization. His work has been instrumental in developing innovative solutions that enhance the understanding and manipulation of gene expression in various applications.
Collaborations
Throughout his career, Holtschke has collaborated with esteemed colleagues, including Konrad Honold and Anne Stern. These partnerships have fostered a collaborative environment that promotes innovation and the sharing of ideas in the field of gene research.
Conclusion
Thomas Holtschke's contributions to gene expression optimization exemplify the impact of innovative thinking in biotechnology. His patented processes not only advance scientific understanding but also pave the way for future developments in genetic research.