Company Filing History:
Years Active: 2000
Title: Thomas D. Sutliff: Innovator in Plant Biotechnology
Introduction
Thomas D. Sutliff is a notable inventor based in Rocklin, CA (US). He has made significant contributions to the field of plant biotechnology, particularly in the production of therapeutic proteins. With a total of 2 patents, his work has the potential to impact medical treatments and agricultural practices.
Latest Patents
Sutliff's latest patents include innovative methods for producing .alpha..sub.1-antitrypsin (AAT) in plants. The first patent discloses a method for cultivating monocot plant cells transformed with an AAT coding sequence under conditions that promote protein expression and secretion. This method also introduces a codon-optimized AAT coding sequence that is efficiently translated in plant cell culture. Additionally, it presents a novel AAT protein with a glycosylation pattern characteristic of plant cells, making it suitable for therapeutic use in humans.
The second patent focuses on the production of mature proteins in plants. It describes a chimeric gene designed for producing a mature protein in a secreted form by stably transformed plant cells. This gene includes a DNA coding sequence for a fusion protein that consists of an N-terminal moiety corresponding to a portion of the rice .alpha.-amylase signal sequence peptide and a protein moiety corresponding to the protein to be produced. The patent also outlines a method for producing a mature protein in secreted form by plant cells.
Career Highlights
Sutliff is currently associated with Applied Phytologics, Inc., where he continues to advance his research in plant biotechnology. His work is characterized by a commitment to developing innovative solutions that leverage plant systems for protein production.
Collaborations
One of his notable collaborators is Raymond L. Rodriguez, with whom he has worked on various projects related to plant biotechnology.
Conclusion
Thomas D. Sutliff's contributions to the field of plant biotechnology through his patents and research at Applied Phytologics, Inc. highlight his role as an innovator in producing therapeutic proteins. His work has the potential to significantly influence both medical and agricultural sectors.