Location History:
- Potomac, MD (US) (1993 - 2001)
- Charleston, SC (US) (1997 - 2004)
Company Filing History:
5 out of 1,217 
2 out of 174 
1 out of 3,540 
Years Active: 1993-2004
Title: Innovations in Cancer Treatment by Takis S Papas
Introduction
Takis S Papas is a prominent inventor based in Potomac, MD (US), known for his significant contributions to cancer research and treatment. With a total of 10 patents, his work focuses on novel genes and their applications in diagnosing and treating various types of cancer.
Latest Patents
One of his latest patents involves methods and compositions for the diagnosis and treatment of cancer. This invention relates to a novel gene, CaSm, which is highly expressed in cancer tissues and cell lines, particularly in pancreatic cancer. The full-length cDNA of CaSm encodes a protein of 133 amino acids and contains two Sm motifs found in common snRNP proteins, showing a 60% similarity to the Sm G protein. The invention also includes CaSm peptides, fusion proteins, host cell expression systems, antibodies to CaSm, antisense CaSm molecules, and compounds that modulate CaSm gene expression or activity. Notably, antisense CaSm RNA can alter the transformed phenotype of pancreatic cancer cells, reducing their ability to form large colonies in soft agar compared to untransfected cells. Additionally, the invention encompasses methods for disease diagnosis, drug screening, and cancer treatment.
Another significant patent focuses on methods and compositions for the diagnosis and treatment of breast cancer. This invention introduces a novel gene, Di12, which is differentially expressed as a 1.35 kb RNA in breast cancer tissues and cell lines, as well as in several normal tissues. The full-length cDNA encodes a protein of 339 amino acids. Antibodies to the gene product were developed to investigate Di12 expression in breast cancer cell lines and tumors. The Di12 protein was found in tissue sections of infiltrating ductal carcinomas (IDCs) but not in benign or normal breast specimens. Its presence in IDC-breast cancer patient sera and the marked increase in expression levels when accompanied by lymph node or distal metastases make Di12 a valuable marker for disease diagnosis, predicting disease progression, and monitoring therapeutic treatment.
Career Highlights
Throughout his career, Takis S Papas has made substantial contributions to the field of cancer research. His innovative approaches have led to advancements in understanding cancer biology and developing targeted therapies.
Collaborations
He has collaborated with notable individuals in the field, including Clifford W Schweinfest