Takamitsu Miyafusa

Title: Takamitsu Miyafusa: Innovator in Cyclized Cytokines

Introduction

Takamitsu Miyafusa is a prominent inventor based in Tsukuba, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of cyclized proteins. His innovative approach aims to enhance the stability and efficiency of protein production.

Latest Patents

Miyafusa holds a patent for "Cyclized cytokines and method for producing same." The purpose of this invention is to provide a method for producing a very stable, cyclized mutant protein. This method achieves high cyclization efficiency while minimizing the number of amino acids added, all while maintaining the biological properties of the original protein. The process involves deleting secondary structure-free regions at the N/C terminal portions of the protein and screening a protein database for similar secondary structures. The results of this screening help determine the amino acid length of a loop structure that connects the N-terminus and C-terminus of the original protein's secondary structure-forming portion. Ultimately, a cyclized mutant protein is produced with the specified loop structure.

Career Highlights

Miyafusa is affiliated with the National Institute of Advanced Industrial Science and Technology, where he conducts his research and development work. His expertise in protein engineering has positioned him as a key figure in advancing biotechnological applications.

Collaborations

Miyafusa collaborates with Shinya Honda, a fellow researcher, to further explore the potential of cyclized proteins and their applications in various fields.

Conclusion

Takamitsu Miyafusa's work in the development of cyclized cytokines represents a significant advancement in biotechnology. His innovative methods and collaborative efforts continue to push the boundaries of protein engineering.