T Scott Reid

Title: T Scott Reid: Innovator in Protein Prenyltransferase Research

Introduction

T Scott Reid is a notable inventor based in Durham, NC (US). He has made significant contributions to the field of biochemistry, particularly in the study of protein geranylgeranyl transferase type I (GGTase-I). His work has implications for understanding various regulatory proteins in eukaryotic cells.

Latest Patents

Reid holds a patent for the structure and uses of geranylgeranyl transferase type I (GGTase-I). This essential enzyme catalyzes the carboxyl-terminal lipidation of over one hundred proteins, including many GTP-binding regulatory proteins. The patent provides a plurality of crystal structures of mammalian GGTase-I in complex with substrates and products. This groundbreaking work offers the first structural information for this enzyme, facilitating the elucidation of a generalized method of action for all protein prenyltransferases. The method includes a role in product transport, revealing specificity determinants that allow classification of putative protein prenyltransferase sequences. This can facilitate the optimization of GGTase-I and FTase modulators.

Career Highlights

Reid's career is marked by his dedication to advancing the understanding of protein prenylation. His research has contributed to the broader field of molecular biology and has implications for therapeutic developments.

Collaborations

Reid has collaborated with esteemed colleagues such as Jeffrey S Taylor and Lorena S Beese. These partnerships have enriched his research and expanded the impact of his findings.

Conclusion

T Scott Reid's innovative work in the field of protein geranylgeranyl transferase type I has paved the way for new insights into enzyme function and regulation. His contributions are vital for future research and potential therapeutic applications.