Sulekha Rao Coticone

Title: Sulekha Rao Coticone: Innovator in Microsatellite Amplification

Introduction

Sulekha Rao Coticone is a prominent inventor based in Half Moon Bay, CA (US). She has made significant contributions to the field of molecular biology, particularly in the area of microsatellite amplification. With a total of 4 patents, her work has advanced the understanding and application of genetic analysis.

Latest Patents

Coticone's latest patents focus on methods for reducing stutter in microsatellite amplification. The invention provides a method that includes steps such as providing a sample with a microsatellite having a G+C content of 50% or less. The sample is then contacted with at least one enzyme that has nucleic acid polymerase activity. The incubation of the sample with the enzyme occurs under conditions sufficient to amplify the microsatellite. Importantly, this process is performed in the presence of an effective amount of betaine, sorbitol, or mixtures thereof, which reduces stutter compared to the absence of these substances. Additionally, her patents include compositions containing betaine and/or sorbitol, kits for amplifying microsatellites, and methods for utilizing these innovations.

Career Highlights

Throughout her career, Coticone has worked with notable organizations, including Applera Corporation and the Applied Biosystems Group of Applera Corporation. Her experience in these companies has allowed her to develop and refine her innovative techniques in genetic research.

Collaborations

Coticone has collaborated with esteemed colleagues such as Will Bloch and Ian J McLaughlin. These partnerships have contributed to her success and the advancement of her research.

Conclusion

Sulekha Rao Coticone is a trailblazer in the field of microsatellite amplification, with her innovative methods and patents paving the way for future advancements in genetic analysis. Her contributions continue to impact the scientific community significantly.