Company Filing History:
Years Active: 2001
Title: Innovations in DNA Polymerase: The Contributions of Steven Evans
Introduction
Steven Evans is a notable inventor based in Gosforth, GB. He has made significant contributions to the field of biotechnology, particularly in the utilization of dideoxynucleotide-triphosphates (ddNTPs) by hyper-thermophilic DNA polymerases. His work has implications for improving DNA sequencing techniques, which are crucial for various applications in genetics and molecular biology.
Latest Patents
Steven Evans holds a patent titled "Dideoxynucleotide-triphosphate utilization by the hyper-thermophilic DNA polymerase from the archaeon Pyrococcus furiosus." This patent focuses on the enhancements made to polymerases from the Pol I family, which have shown improved performance in DNA sequencing when utilizing ddNTPs. The research involved making several mutations to the gene coding for the Pol II family DNA polymerase from the archaeon, aiming to enhance ddNTP utilization. Notably, alterations at four specific positions (Q472, A486, L490, and Y497) resulted in variants that incorporated ddNTPs more effectively than the wild type, allowing for sequencing reactions to be conducted at lower ddNTP:dNTP ratios.
Career Highlights
Steven Evans is associated with Amersham Pharmacia Biotech, Inc., where he has contributed to advancements in biotechnological research. His innovative approach to modifying DNA polymerases has led to significant improvements in the efficiency of DNA sequencing, which is vital for research in genomics and related fields.
Collaborations
Throughout his career, Steven has collaborated with notable colleagues such as Joseph Anthony Mamone and Maria Cuozzo Davis. These collaborations have likely enriched his research and contributed to the successful outcomes of his projects.
Conclusion
Steven Evans is a prominent inventor whose work in enhancing DNA polymerases has the potential to revolutionize DNA sequencing methodologies. His contributions are invaluable to the field of biotechnology and continue to influence research and applications in genetics.