Company Filing History:
Years Active: 1996
Title: Innovations in Nerve Growth: The Contributions of Stephen M. Strittmatter
Introduction
Stephen M. Strittmatter is a prominent inventor based in Clinton, CT (US). He has made significant contributions to the field of neuroscience, particularly in understanding nerve growth and regeneration. His innovative work has led to the development of a patent that addresses critical challenges in nerve growth inhibition.
Latest Patents
Stephen M. Strittmatter holds a patent for "Peptides to overcome inhibition of nerve growth." This invention focuses on the inhibition of nerve growth, which is essential for preventing aberrant pathway selection but also hinders necessary regeneration in the mammalian central nervous system. The patent explores the role of unknown inhibitory ligands and the involvement of pertussis toxin-sensitive G proteins in the collapse of responding growth cones. By utilizing GAP-43 peptides, Strittmatter aims to modify the sensitivity of nerves to these inhibitory signals. His research indicates that the native amino terminus sequence of the peptide stimulates G.sub.o, enhancing growth cone collapse induced by inhibitory ligands. Furthermore, modifications to critical cysteines in the peptides have shown promise in inhibiting G.sub.o, significantly reducing inhibitor-mediated growth cone collapse.
Career Highlights
Stephen M. Strittmatter is associated with The General Hospital Corporation, where he has been able to apply his research in a practical setting. His work has not only advanced scientific understanding but also has potential therapeutic implications for nerve regeneration.
Collaborations
Throughout his career, Strittmatter has collaborated with notable colleagues, including Mark C. Fishman and Michihiro Igarashi. These collaborations have enriched his research and contributed to the advancement of knowledge in the field of neuroscience.
Conclusion
Stephen M. Strittmatter's innovative work in developing peptides to overcome nerve growth inhibition represents a significant advancement in neuroscience. His contributions have the potential to pave the way for new therapeutic strategies in nerve regeneration.