Company Filing History:
1 out of 832,891 Years Active: 2001
Title: Innovations in Immunology: The Work of Siri Mjaaland
Introduction
Siri Mjaaland is a notable inventor based in Oslo, Norway. He has made significant contributions to the field of immunology, particularly through his innovative patent related to modified immunoglobulin molecules. His work aims to enhance the immune response, especially in cases where the immune system has become tolerant to certain proteins.
Latest Patents
Siri Mjaaland holds a patent for a "Modified immunoglobulin molecule incorporating an antigen in a non-CDR loop region." This invention involves a modified immunoglobulin (Ig) molecule that incorporates foreign antigenic peptides, such as a ras peptide, in one or more non-CDR loops. The antigen binding site of the immunoglobulin is designed to recognize dendritic antigen presenting cells (APCs). This allows the modified Ig to be taken up by dendritic APCs, presenting the foreign antigenic peptide on MHC II to naive T-helper cells. This process stimulates cytotoxic T-cells through the production of interleukin-2 (IL-2). The modified Igs can be utilized to stimulate the immune system, particularly in cases of cancer or for vaccination against viral infections. The modified Ig can be expressed from recombinant host cells, ensuring its secretion despite the presence of the foreign peptide.
Career Highlights
Siri Mjaaland has dedicated his career to advancing immunological research. His innovative approaches have opened new avenues for therapeutic interventions in cancer and viral infections. His work is characterized by a strong focus on enhancing the immune response through novel immunoglobulin modifications.
Collaborations
Siri has collaborated with esteemed colleagues in the field, including Bjarne Bogen and Inger Sandlie. These collaborations have further enriched his research and contributed to the development of groundbreaking immunological therapies.
Conclusion
Siri Mjaaland's contributions to immunology through his patented innovations demonstrate the potential for modified immunoglobulin molecules to revolutionize treatments for cancer and viral infections. His work exemplifies the intersection of scientific research and practical application in the field of medicine.