Simon Daniel Spivack

Title: Simon Daniel Spivack: Innovator in Genomic DNA Sequencing

Introduction

Simon Daniel Spivack is a notable inventor based in Nassau, NY (US). He has made significant contributions to the field of genomic DNA sequencing, particularly in the area of DNA methylation evaluation. His innovative methods have the potential to impact cancer diagnostics and research.

Latest Patents

Simon Daniel Spivack holds a patent for his invention titled "GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra." This invention relates to a tag-modified bisulfite genomic sequencing (tBGS) method developed for simplified evaluation of DNA methylation sites. The method employs direct cycle sequencing of PCR products at kilobase scale, without conventional DNA fragment cloning. It entails subjecting bisulfite-modified genomic DNA to a second-round PCR amplification employing GC-tagged primers. Additionally, the invention includes a method for identifying a patient at risk for lung cancer using the tBGS technique disclosed.

Career Highlights

Throughout his career, Simon has focused on advancing genomic technologies. His work has been instrumental in developing methods that enhance the understanding of DNA methylation, which is crucial for various biological processes and disease mechanisms.

Collaborations

Simon has collaborated with notable colleagues, including James Gordon Herman and Weiguo Han. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.

Conclusion

Simon Daniel Spivack is a pioneering inventor whose work in genomic DNA sequencing has the potential to revolutionize the evaluation of DNA methylation and improve cancer diagnostics. His contributions to the field are significant and continue to influence ongoing research and innovation.