Company Filing History:
1 out of 832,880 Years Active: 2001
Title: Sigbjørn Fossum: Innovator in Immunology
Introduction
Sigbjørn Fossum is a notable inventor based in Oslo, Norway. He has made significant contributions to the field of immunology, particularly through his innovative patent related to modified immunoglobulin molecules. His work aims to enhance the immune response, especially in cases where the immune system has become tolerant to certain proteins.
Latest Patents
Fossum holds a patent for a "Modified immunoglobulin molecule incorporating an antigen in a non-CDR loop region." This invention involves a modified immunoglobulin (Ig) molecule that incorporates foreign antigenic peptides, such as a ras peptide, in one or more non-CDR loops. The antigen binding site of the immunoglobulin is designed to recognize dendritic antigen presenting cells (APCs). This allows the modified Ig to be taken up by dendritic APCs, facilitating the presentation of the foreign antigenic peptide on MHC II to naive T-helper cells. This process stimulates cytotoxic T-cells through the production of interleukin-2 (IL-2). The modified Igs can be utilized to stimulate the immune system, particularly in cases of cancer or for vaccination against viral infections. Fossum's patent represents a significant advancement in immunotherapy.
Career Highlights
Throughout his career, Sigbjørn Fossum has focused on the intersection of immunology and biotechnology. His innovative approaches have led to advancements in how the immune system can be manipulated to respond to various diseases. His work is characterized by a commitment to improving therapeutic strategies for conditions that challenge the immune system.
Collaborations
Fossum has collaborated with esteemed colleagues in the field, including Bjarne Bogen and Inger Sandlie. These partnerships have fostered a collaborative environment that enhances research and development in immunology.
Conclusion
Sigbjørn Fossum's contributions to the field of immunology through his innovative patent demonstrate his commitment to advancing medical science. His work has the potential to significantly impact therapeutic approaches to cancer and viral infections.