Si-Tse Jiang

Title: Innovations of Si-Tse Jiang

Introduction

Si-Tse Jiang is a prominent inventor based in Tainan, Taiwan. He has made significant contributions to the field of biomedical engineering, particularly in the development of novel therapeutic methods. His work focuses on addressing diseases caused by protein retention in the endoplasmic reticulum.

Latest Patents

Si-Tse Jiang holds a patent for "Endoplasmic reticulum-targeting nanovehicles and methods for use thereof." This innovative method involves treating diseases caused by protein retention in the endoplasmic reticulum (ER) using a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle. The polymer nanoparticle is designed to target the ER specifically. The inhibitor effectively reduces protein retention in the ER, while the encapsulation minimizes side effects, such as cytotoxicity, compared to administering the inhibitor without encapsulation. Additionally, the patent includes a pharmaceutical composition for implementing the method and describes a transgenic mouse model for human chronic granulomatous disease.

Career Highlights

Si-Tse Jiang is affiliated with National Cheng Kung University, where he continues to advance his research and innovations. His work has garnered attention for its potential impact on treating various diseases linked to protein misfolding and retention.

Collaborations

Si-Tse Jiang collaborates with notable colleagues, including Chi-Chang Shieh and Chia-Liang Yen. Their combined expertise enhances the research and development of innovative solutions in the biomedical field.

Conclusion

Si-Tse Jiang's contributions to the field of biomedical engineering, particularly through his patent on endoplasmic reticulum-targeting nanovehicles, highlight his role as a leading inventor. His work promises to pave the way for new therapeutic approaches in treating complex diseases.