Company Filing History:
Years Active: 1996-1997
Title: Innovations by Shuyuan Zhang in Retroviral Vector Technology
Introduction
Shuyuan Zhang is a notable inventor based in Gaithersburg, MD (US), recognized for his contributions to the field of gene therapy. He holds three patents that focus on the purification and transduction of retroviral vectors, which are crucial for advancing gene therapy techniques.
Latest Patents
One of his latest patents is titled "Purification of retroviral vectors." This invention describes a method for purifying retroviral vector particles by culturing producer cells capable of generating these particles. The process involves obtaining a supernatant from the culture, clarifying and concentrating it, and then using a precipitation agent followed by centrifugation to recover retroviral particles. This method significantly enhances the recovery of retroviral vector particles, which can be utilized in gene therapy applications.
Another significant patent is the "Method of transduction of cells with retroviral vectors." This invention introduces an efficient technique known as spin transduction. In this method, retroviral particles suspended in a pharmaceutically acceptable carrier are mixed with the target cells and centrifuged. This process results in a 3- to 15-fold increase in transduction efficiency, depending on the type of cells being transduced.
Career Highlights
Shuyuan Zhang is currently employed at Genetic Therapy, Inc., where he continues to innovate in the field of gene therapy. His work has been instrumental in developing methods that improve the efficiency and effectiveness of retroviral vectors.
Collaborations
Some of his notable coworkers include Hitoshi Kotani and Perry Newton, III. Their collaborative efforts contribute to the advancement of research and development in genetic therapies.
Conclusion
Shuyuan Zhang's innovative work in retroviral vector technology has the potential to significantly impact gene therapy practices. His patents reflect a commitment to enhancing the efficiency of gene delivery systems, paving the way for future advancements in medical treatments.