Company Filing History:
Years Active: 2013-2014
Title: Innovations of Shu-Fen Huang
Introduction
Shu-Fen Huang is a notable inventor based in Taoyuan Hsien, Taiwan. He has made significant contributions to the field of biotechnology, particularly in the development of pharmaceutical processes. With a total of 2 patents, his work has garnered attention for its innovative approaches and practical applications.
Latest Patents
One of his latest patents is a process for preparing 4-borono-L-phenylalanine. This process involves reacting N-protected (S)-4-halophenylalanine with a boronating agent and an organolithium to create a reaction mixture. The resulting mixture contains N-protected (S)-4-boronophenylalanine, which is crucial for various biochemical applications.
Another significant patent is a method for making donepezil. This method includes mixing E2M with an organic solvent, a weak base, sodium dithionite, and a phase transfer catalyst. The mixture is then heated, and water is added to create a heated E2M aqueous solution. The organic layer is extracted, condensed, and dried to obtain donepezil. This innovative method improves safety by using sodium dithionite as a reducing agent instead of hydrogen gas, which is commonly used in traditional methods. Additionally, it reduces costs compared to conventional noble metal catalysts. The process is efficient, requiring only 60 minutes of reaction time to synthesize donepezil with a promising yield of over 85%.
Career Highlights
Shu-Fen Huang is associated with Taiwan Biotech Co., Ltd., where he continues to advance his research and development efforts. His work has not only contributed to the field of pharmaceuticals but has also enhanced the economic value of drug manufacturing.
Collaborations
Shu-Fen has collaborated with notable colleagues, including Kuen-Wang Sheu and Chia-Cheng Shaw, who have contributed to his research endeavors.
Conclusion
Shu-Fen Huang's innovative patents and contributions to biotechnology exemplify the impact of research on pharmaceutical development. His work continues to influence the industry and improve drug manufacturing processes.