Shu-Fen Coker

Title: Shu-Fen Coker: Innovator in VNAR Polypeptides

Introduction

Shu-Fen Coker is a prominent inventor based in Amersham, GB. She has made significant contributions to the field of biotechnology, particularly in the development of VNAR polypeptides. Her work focuses on creating innovative solutions for delivering biomolecules across biological barriers.

Latest Patents

Shu-Fen Coker holds a patent for "Type-II VNAR polypeptides which bind human TfR-1, encoding nucleic acids thereof and method of use thereof." This invention relates to a high-affinity VNAR polypeptide that is cross-reactive with primate transferrin receptors (TfR). The VNAR polypeptides were obtained by screening semisynthetic VNAR phage display libraries against recombinant human TfR-1. These polypeptides can be utilized alone or as components in conjugates targeting the transferrin/transferrin receptor transport system. The invention also includes applications in diagnostic and therapeutic methods, particularly for delivering biomolecules across the blood-brain barrier and other membrane systems. Additionally, the VNAR polypeptide can target biological barriers such as the intestines and the placenta, providing therapeutic benefits in treating certain cancer cells and tumors.

Career Highlights

Shu-Fen Coker is associated with Ossianix, Inc., where she continues to advance her research and development efforts. Her innovative work has positioned her as a key figure in the biotechnology sector, contributing to the understanding and application of VNAR polypeptides.

Collaborations

Shu-Fen has collaborated with notable colleagues, including Pawel Stocki and Jaroslaw Michal Szary. These collaborations have further enhanced her research capabilities and broadened the impact of her inventions.

Conclusion

Shu-Fen Coker's contributions to the field of VNAR polypeptides exemplify her dedication to innovation in biotechnology. Her patented work holds promise for significant advancements in medical diagnostics and therapeutics.