Shreeram Akilesh

Title: Innovations in Genomic Analysis by Shreeram Akilesh

Introduction

Shreeram Akilesh is a prominent inventor based in Bangor, ME (US), known for his contributions to genomic analysis. He holds 2 patents that focus on advanced systems and methods for evaluating genomic DNA. His work is pivotal in the fields of genetic research and diagnostics, particularly in understanding variations in DNA sequences.

Latest Patents

One of Akilesh's latest patents is titled "Systems and methods for statistical genomic DNA based analysis and evaluation." This invention provides a framework for performing rapid genomic DNA analysis of various samples, including control and experimental samples. The system utilizes genomic DNA input rather than gene expression input, allowing for a more accurate assessment of DNA sequence variations. It employs statistical analyses to identify significant variations in DNA sequences, which can be crucial for diagnosing conditions such as cancer. Additionally, it offers a quantitative measure of variation based on metrics like copy number and fold-change.

Another significant patent is "Expression data analysis systems and methods," which describes methods and applications of Global Pattern Recognition (GPR). This system analyzes results from real-time polymerase chain reaction (RT-PCR) experiments using micro-titer and microarray plates. It incorporates self-normalizing housekeeping primers to enhance the accuracy of expression data normalization. The system generates a ranked list of genes with statistically significant changes, improving the reliability of genomic analyses.

Career Highlights

Shreeram Akilesh is affiliated with The Jackson Laboratory, a leading research institution focused on genetics and genomics. His work at this esteemed organization has allowed him to contribute significantly to the field of genomic research. His innovative approaches have the potential to transform how genetic evaluations are conducted, particularly in clinical settings.

Collaborations

Throughout his career, Akilesh has collaborated with notable colleagues, including Derry Roopenian and Daniel J. Shaffer. These collaborations have further enriched his research and expanded the impact of his inventions in the scientific community.

Conclusion

Shreeram Akilesh's contributions to genomic analysis through his innovative patents are shaping the future of genetic research and diagnostics. His work exemplifies the importance of advancements in technology for understanding complex biological systems.