Shinichi Muramatsu

Title: Innovations by Shinichi Muramatsu

Introduction

Shinichi Muramatsu is a notable inventor based in Tochigi, Japan. He has made significant contributions to the field of gene therapy, particularly in the treatment of genetic disorders. With a total of three patents to his name, his work focuses on innovative methods for delivering therapeutic genes to nervous system cells.

Latest Patents

One of his latest patents involves an adeno-associated virus virion for the treatment of Tay-Sachs disease and Sandhoff disease. This invention addresses the need for frequent administration of a modified β-subunit to patients. It comprises a recombinant adeno-associated virus virion that includes a capsomere capable of forming a virus virion and a polynucleotide packaged within it. This polynucleotide contains a promoter sequence and nucleotide sequences that encode a modified β-subunit of human β-hexosaminidase.

Another significant patent by Muramatsu is for an adeno-associated virus virion designed for gene transfer to nervous system cells. This invention provides a highly efficient method for transferring therapeutic genes into nervous system cells using a recombinant vector based on adeno-associated virus (AAV). The recombinant adeno-associated virus virions are capable of crossing the blood-brain barrier, making them a promising tool for gene therapy.

Career Highlights

Shinichi Muramatsu has worked at prestigious institutions such as Jichi Medical University and Tokushima