Shi-Hsiang Shen

Title: Shi-Hsiang Shen: Innovator in Gene Expression Systems

Introduction

Shi-Hsiang Shen is a notable inventor based in Beaconsfield, CA. He has made significant contributions to the field of gene expression systems, holding a total of 9 patents. His work has implications for biotechnology and molecular biology, showcasing innovative approaches to gene regulation.

Latest Patents

One of Shen's latest patents is the Coumermycin/novobicin-regulated gene expression system. This invention features a chimeric transactivator that includes a transcription activation domain, a repressor protein DNA binding domain, and the bacterial DNA gyrase B subunit. The target gene is operatively linked to operator DNA sequences recognized by the repressor binding domain. The addition of the antibiotic coumermycin leads to a coumermycin-switched dimerization of the transactivator, which then binds to operator DNA sequences and activates transcription of the target gene. Conversely, the addition of novobiocin switches off expression of the target gene by abolishing coumermycin-induced dimerization of the transactivator.

Career Highlights

Throughout his career, Shi-Hsiang Shen has worked with esteemed organizations such as the National Research Council of Canada and Her Majesty the Queen in Right of Canada, as represented by the National Research Council. His work in these institutions has allowed him to advance his research and contribute to significant scientific developments.

Collaborations

Shen has collaborated with notable colleagues, including Sultan Ahmad and Claes Wahlestedt. These partnerships have enriched his research and expanded the impact of his innovations in gene expression systems.

Conclusion

Shi-Hsiang Shen's contributions to gene expression systems through his innovative patents and collaborations highlight his role as a leading inventor in the field. His work continues to influence advancements in biotechnology and molecular biology.