Company Filing History:
Years Active: 2007-2016
Title: Innovations of Sau-Ching Wu in Biochemical Engineering
Introduction
Sau-Ching Wu is a notable inventor based in Calgary, Canada. He has made significant contributions to the field of biochemical engineering, particularly in the development of streptavidin muteins. With a total of four patents to his name, his work has the potential to impact various applications in biotechnology.
Latest Patents
One of his latest patents is titled "Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins." This invention relates to new streptavidin muteins that can bind both streptavidin binding peptide tagged and biotin or biotinylated molecules in a reversible manner. This characteristic allows for stability and reuse, making it a cost-effective solution in production without the need for complex refolding processes.
Another significant patent is "Tetrameric streptavidin mutein with reversible biotin binding capability." This invention describes muteins capable of oligomerization to form tetramers, which exhibit strong subunit interactions. The dissociation constant for biotin in this mutein is in the range of 10 to 10M, with an off-rate for the bound biotin in the streptavidin-biotin complex in the range of 10 seconds. This mutein is also stable enough for reuse and can be produced with reasonable yield through secretion in a soluble functional state.
Career Highlights
Sau-Ching Wu is currently associated with Uti Limited Partnership, where he continues to innovate in the field of biochemistry. His work is characterized by a focus on creating efficient and effective solutions for biotechnological applications.
Collaborations
He has collaborated with notable coworkers such as Sui-Lam Wong and Isabelle Barrette-Ng, who contribute to the innovative environment in which he works.
Conclusion
Sau-Ching Wu's contributions to the field of biochemical engineering through his patents on streptavidin muteins demonstrate his commitment to advancing biotechnology. His work not only enhances the understanding of biotin binding but also paves the way for more efficient production methods in the industry.