Sang-Ki Rhee

Title: The Innovative Contributions of Sang-Ki Rhee

Introduction

Sang-Ki Rhee is a prominent inventor based in Seoul, South Korea. He has made significant contributions to the field of biotechnology, particularly in the production of interleukin-2 proteins. With a total of seven patents to his name, Rhee's work has had a substantial impact on medical and biotechnological advancements.

Latest Patents

One of Rhee's latest patents is a method for producing interleukin-2 protein using methylotrophic yeast. This innovative method demonstrates high cell growth and protein synthesis rates by utilizing an established optimal cell line. It allows for the production of large amounts of interleukin-2 protein through optimal culture conditions that employ methanol as an inexpensive carbon source. Additionally, this method simplifies the isolation and purification process of the protein, resulting in highly pure interleukin-2, which is crucial for mass production.

Another notable patent is the interleukin-2 expression construct using human serum albumin. This construct comprises a methanol oxidase (MOX) promoter, a human serum albumin gene, and an interleukin-2 gene. The expression construct enables the production of a fusion protein of human serum albumin and interleukin-2 at low costs, facilitating the easy separation of recombinant interleukin-2 from the fusion protein. This innovation is expected to enhance the large-scale production of recombinant interleukin-2 with high purity.

Career Highlights

Sang-Ki Rhee has worked with esteemed organizations such as the Korea Research Institute of Bioscience and Biotechnology and Soonchunhyang University Industry Academy Cooperation Foundation. His experience in these institutions has allowed him to further his research and development in biotechnology.

Collaborations

Rhee has collaborated with notable colleagues, including Hyun-Ah Kang and Eui-Sung Choi. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.

Conclusion

Sang-Ki Rhee's innovative work in the field of biotechnology, particularly in the production of interleukin-2 proteins, showcases his significant contributions to medical science. His patents reflect a commitment to advancing biotechnological methods that can lead to improved healthcare solutions.