Samuel Saporta

Title: Innovations of Samuel Saporta

Introduction

Samuel Saporta is a notable inventor based in Tampa, Florida. He has made significant contributions to the field of biotechnology, particularly in the area of stem cell research. With a total of 4 patents, his work focuses on advancing methods for cell differentiation and transplantation.

Latest Patents

One of his latest patents is titled "Stable differentiation of NT2 cells." This invention describes a method for differentiating adult stem cells derived from the Ntera2/D1 clone (NT2). The developed cells exhibit a stable neurotransmitter phenotype without the need for growth factors or retinoic acid, which can be challenging to eliminate during commercial production. This method allows for the identification of specific neurotransmitters in differentiated NT2-derived neurons after 30 days in culture or survival in vivo. The invention aims to stably differentiate neuronal stem/precursor cells for use in cell replacement therapy for neurodegenerative diseases, stroke, or spinal cord injuries. The method produces at least four different types of neurons: dopaminergic, cholinergic, GABAergic, and glutaminergic. Additionally, since the cells are cancer stem cells prior to differentiation, they may serve as a model system for developing anti-cancer therapies targeting the cancer stem cell rather than the more differentiated daughter cell.

Another significant patent is "Sertoli cells as biochambers." This invention provides a biological chamber system defined by outer walls of Sertoli cells. It includes a transplantation facilitator and a method for making biochambers by co-culturing facilitator cells and therapeutic cells. The method also outlines how to transplant cells by incorporating transplant cells into a biochamber and then transplanting the entire biochamber.

Career Highlights

Samuel Saporta is affiliated with the University of South Florida, where he continues to contribute to research and innovation in biotechnology. His work has garnered attention for its potential applications in regenerative medicine and cancer therapy.

Collaborations

Some of his notable coworkers include Don F Cameron and Paul R Sanberg, who have collaborated with him on various research projects.

Conclusion

Samuel Saporta's innovative work in stem cell research and biotechnology has the potential to significantly impact medical therapies for neurodegenerative diseases and cancer. His contributions through his patents reflect a commitment to advancing scientific knowledge and improving patient outcomes.