Sabine Arndt

Title: Sabine Arndt: Innovator in Protein Glycosylation Detection

Introduction

Sabine Arndt is a prominent inventor based in Dortmund, Germany. She has made significant contributions to the field of biochemistry, particularly in the detection of protein glycosylation. With a total of six patents to her name, her work has implications for various disease states, including cancer and neurodegeneration.

Latest Patents

One of her latest patents focuses on methods and compositions for the rapid and sensitive detection of post-translationally modified proteins. This invention specifically addresses the detection of O-GlcNAc posttranslational modifications on proteins that were previously undetectable using traditional techniques. The method utilizes a mutant form of β-1,4-galactosyltransferase to transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. This ketone moiety serves as a versatile handle for biotin attachment, enabling the visualization of modified proteins that are at the limits of detection with conventional methods. The preferred embodiments of this invention can also be applied to detect various disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.

Career Highlights

Throughout her career, Sabine Arndt has worked with esteemed institutions, including the California Institute of Technology and Bayer Intellectual Property GmbH. Her innovative research has positioned her as a key figure in the field of protein detection.

Collaborations

Some of her notable coworkers include Nelly Khidekel and Hwan-Ching Tai, who have contributed to her research endeavors.

Conclusion

Sabine Arndt's work in the detection of protein glycosylation represents a significant advancement in biochemistry. Her innovative methods have the potential to enhance the understanding and diagnosis of various diseases.