Sabena Uddowla

Title: Innovations by Sabena Uddowla in Vaccine Development

Introduction

Sabena Uddowla is an accomplished inventor based in Ivoryton, Connecticut, known for his significant contributions to vaccine development. He holds two patents that focus on innovative solutions for combating foot and mouth disease (FMD) in livestock. His work is crucial in enhancing animal health and preventing the spread of this viral disease.

Latest Patents

Uddowla's latest patents involve the development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host. He has generated novel molecularly marked FMDV ALL3D and ALL3B3D vaccine candidates. The mutant viruses contain a deletion of the leader coding region (LL), rendering the virus attenuated in vivo. Negative antigenic markers have been introduced in one or both of the viral non-structural 3D and 3B proteins. The vaccine platform includes unique restriction endonuclease sites for easy swapping of capsid proteins for different FMDV subtypes and serotypes. The mutant viruses produced no signs of FMD and no shedding of virulent virus in cattle. No clinical signs of disease or fever were observed, and no transmission to in-contact animals was detected in pigs inoculated with live ALL3D. Cattle immunized with chemically inactivated vaccine candidates showed an efficacy comparable to a polyvalent commercial FMDV vaccine. These vaccine candidates, used in conjunction with a cELISA, provide a suitable target for DIVA companion tests.

Career Highlights

Uddowla works for the United States of America, as represented by the Secretary of Agriculture. His research and innovations have made a significant impact on the field of veterinary medicine and public health.

Collaborations

Some of his notable coworkers include Aida Elizabeth Rieder and Luis Leandro Rodriguez, who have collaborated with him on various projects related to vaccine development.

Conclusion

Sabena Uddowla's innovative work in developing vaccines for foot and mouth disease showcases his dedication to improving animal health and preventing disease transmission. His contributions are vital for the agricultural sector and public health initiatives.