Location History:
- Exton, PA (US) (1997)
- San Diego, CA (US) (1993 - 1998)
Company Filing History:
1 out of 22 
1 out of 3 
1 out of 366 
Years Active: 1993-1998
Title: Russell A Brierley: Innovator in Biotechnology
Introduction
Russell A Brierley is a prominent inventor based in San Diego, CA (US). He has made significant contributions to the field of biotechnology, particularly in the expression of proteins using yeast systems. With a total of 4 patents, his work has advanced the understanding and application of recombinant DNA technology.
Latest Patents
One of Brierley's latest patents is focused on the expression of human serum albumin in Pichia pastoris. This invention involves expression cassettes that include a 5' regulatory region from various Pichia pastoris genes, operably linked to a human serum albumin (HSA) structural gene. The design ensures that the HSA gene has a translational start codon positioned within 0 to 11 deoxyribonucleotides from its 5' end, linked to a 3' termination sequence. The invention also specifies the adenine and thymine content of the intervening deoxyribonucleotides, which ranges from about 55 to about 64%. Additionally, the expression cassette can be an autonomously replicating vector or an integrative vector. Another notable patent involves the production of insulin-like growth factor-1 (IGF-1) in methylotrophic yeast cells. This process utilizes transformants containing DNA encoding IGF-1, linked with a signal sequence for effective protein secretion. The invention also provides DNA constructs and recombinant strains for the expression and secretion of IGF-1.
Career Highlights
Brierley has worked with notable organizations, including the Salk Institute Biotechnology Industrial Associates, Inc. and the Salk Institute Biotechnology/Industrial Associates, Inc. His work in these institutions has allowed him to explore innovative solutions in biotechnology and protein expression.
Collaborations
Throughout his career, Brierley has collaborated with esteemed colleagues such as Gregory C Holtz and Geneva R Davis. These partnerships have contributed to the advancement of his research and the successful development of his patents.
Conclusion
Russell A Brierley is a distinguished inventor whose work in biotechnology has led to significant advancements in protein expression technologies. His contributions continue to impact the field and inspire future innovations.