Location History:
- Birmingham, AL (US) (1997 - 2005)
- Marietta, GA (US) (2000 - 2005)
Company Filing History:
Years Active: 1997-2005
Title: The Innovative Contributions of Ruiwen Zhang
Introduction
Ruiwen Zhang is a prominent inventor based in Marietta, GA, known for his significant contributions to the field of biotechnology. With a total of six patents to his name, Zhang has made remarkable advancements in cancer research and gene therapy.
Latest Patents
One of Zhang's latest patents is focused on MDM2-specific antisense oligonucleotides. This invention provides methods to activate tumor suppressors and includes antisense oligonucleotides that are complementary to a portion of the MDM2-encoding RNA. These oligonucleotides can be used as analytical and diagnostic tools, potentiators of transgenic animal studies, and potential therapeutic agents for gene therapy approaches. Additionally, the invention outlines methods to augment and synergistically activate a tumor suppressor in conjunction with DNA-damage inducing agents. It also presents in vitro and in vivo models to evaluate the therapeutic effectiveness of a recently identified anti-human-MDM2 antisense oligonucleotide in treating human colorectal cancers.
Another significant patent by Zhang is a method of down-regulating gene expression. This method involves administering a pharmacological formulation comprising a chimeric oligonucleotide that is complementary to the target gene. The oligonucleotide is designed to be orally administered to an animal and includes various types of internucleotide linkages, enhancing its effectiveness in gene regulation.
Career Highlights
Zhang's career is marked by his innovative research and development in the biotechnology sector. He has been instrumental in advancing methods that have the potential to revolutionize cancer treatment and gene therapy. His work has garnered attention for its practical applications in medical science.
Collaborations
Zhang has collaborated with notable professionals in his field, including Sudhir Agrawal and Robert B Diasio. These collaborations have further enriched his research and contributed to the success of his inventions.
Conclusion
Ruiwen Zhang's contributions to biotechnology and cancer research through his patents demonstrate his commitment to innovation and improving therapeutic strategies. His work continues to inspire advancements in the field, making a significant impact on medical science.