Company Filing History:
Years Active: 1999-2004
Title: Innovations of Rosario Leopardi in Herpes Simplex Virus Research
Introduction
Rosario Leopardi is a notable inventor based in Chicago, IL, who has made significant contributions to the field of virology, particularly in the study of herpes simplex virus (HSV). With a total of four patents to his name, Leopardi's work focuses on understanding the mechanisms of viral gene transactivation and apoptosis inhibition.
Latest Patents
Leopardi's latest patents include groundbreaking research on the ICP4 protein of herpes simplex virus. His first patent discusses how ICP4 acts as an inhibitor of apoptosis, revealing that this protein plays a crucial role in transactivating viral genes while also possessing the ability to inhibit apoptosis. This function is attributed to a distinct functional domain separate from its transactivating role. The patent outlines methods for inhibiting apoptosis using ICP4 or an ICP4 encoding gene, as well as approaches for producing recombinant proteins and treating HSV infections.
Another significant patent by Leopardi focuses on the role of both US3 and ICP4 as inhibitors of apoptosis. This invention further explores the necessity of a functional U3 gene, which encodes a protein kinase essential for blocking apoptosis. The patent details methods for inhibiting U3's apoptosis-inhibiting function and the production of recombinant proteins for HSV treatment.
Career Highlights
Leopardi is currently associated with Arch Development Corporation, where he continues to advance his research in virology. His work has been instrumental in developing therapeutic strategies against HSV infections, contributing to the broader understanding of viral pathogenesis.
Collaborations
Leopardi collaborates with Bernard Roizman, a prominent figure in the field of virology. Their partnership has led to significant advancements in the understanding of herpes simplex virus and its interactions with host cellular mechanisms.
Conclusion
Rosario Leopardi's innovative research and patents have made a substantial impact on the field of virology, particularly in the study of herpes simplex virus. His contributions continue to pave the way for new therapeutic approaches in combating viral infections.