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Years Active: 2021-2024
Title: Rosa Barreira Da Silva: Innovator in Immunotherapy
Introduction
Rosa Barreira Da Silva is a prominent inventor based in San Francisco, CA. She has made significant contributions to the field of immunotherapy, particularly through her innovative research and patents. With a total of 3 patents, her work focuses on enhancing tumor immunity and improving therapeutic strategies.
Latest Patents
One of her latest patents is titled "Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy." This groundbreaking research demonstrates that the success of anti-tumor immune responses relies on effector T cells infiltrating solid tumors, a process guided by chemokines. The study reveals that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhances tumor rejection by preserving biologically active CXCL10 and increasing lymphocyte trafficking into the tumor. Furthermore, DPP4 inhibition improves adjuvant-based immunotherapy, adoptive T cell transfer, and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors as a strategy to enhance tumor immunotherapy.
Career Highlights
Rosa has worked with esteemed organizations such as Institut Pasteur and the Institut National de la Santé et de la Recherche Médicale. Her experience in these institutions has allowed her to collaborate with leading experts in the field and contribute to significant advancements in medical research.
Collaborations
Rosa has collaborated with notable professionals, including Matthew Albert, to further her research and innovations in immunotherapy.
Conclusion
Rosa Barreira Da Silva is a trailblazer in the field of immunotherapy, with her innovative patents paving the way for enhanced cancer treatment strategies. Her work continues to inspire advancements in medical research and therapeutic applications.