Company Filing History:
Years Active: 1990-2005
Title: The Innovations of Ronald B Frazier
Introduction
Ronald B Frazier is a notable inventor based in Lake St. Louis, MO (US). He has made significant contributions to the field of biotechnology, particularly in the area of aminopeptidases and somatotropins. With a total of 2 patents, his work has implications for both scientific research and potential therapeutic applications.
Latest Patents
Frazier's latest patents include a groundbreaking discovery related to human methionine aminopeptidase type 3. This enzyme plays a crucial role in the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. The newly identified MetAP-3 exhibits substrate specificity similar to MetAP-1 and MetAP-2, but it is not inhibited by fumagillin, an irreversible inhibitor of MetAP-2. Additionally, MetAP-3 preferentially localizes to mitochondria, which distinguishes it from its counterparts that accumulate in the cytoplasm. His patent also covers human cDNAs encoding polypeptides comprising MetAP-3, along with methods for utilizing these nucleic acid molecules to generate polypeptides and fragments. Another significant patent involves a method for recovering biologically active somatotropins produced as insoluble refractile bodies in transformed microorganisms. This method includes dissolving the refractile bodies in a denaturant and 2-amino-2-methyl-1-propanol, followed by homogenization and dilution to facilitate proper folding.
Career Highlights
Throughout his career, Ronald B Frazier has worked with prominent companies such as Monsanto Company and Pharmacia Corporation. His experience in these organizations has contributed to his expertise in biotechnology and innovation.
Collaborations
Frazier has collaborated with notable colleagues, including Yasuo Konishi and Carolyn J Sympson. These partnerships have likely enriched his research and development efforts.
Conclusion
Ronald B Frazier's contributions to biotechnology through his patents and collaborations highlight his role as an influential inventor in the field. His work continues to pave the way for advancements in understanding and utilizing aminopeptidases and somatotropins.