Company Filing History:
3 out of 988 
2 out of 2,010 
Years Active: 1995-1998
Title: The Innovations of Robert T Fremeau, Jr.
Introduction
Robert T Fremeau, Jr. is a notable inventor based in Durham, NC (US). He has made significant contributions to the field of neuroscience through his innovative research and patents. With a total of 3 patents, Fremeau has focused on the mechanisms of neurotransmission and the role of specific transporters in the central nervous system.
Latest Patents
Fremeau's latest patents include groundbreaking work on high affinity L-proline transporter polypeptides and antibodies. His research describes the anatomical distribution, nucleic acid sequence, pharmacological properties, and inferred structural features of a cDNA encoding a high affinity, Na.sup.+ -dependent rat brain L-proline transporter. This transporter plays a crucial role in excitatory amino acid neurotransmission, supporting a synaptic role for L-proline in specific excitatory pathways in the CNS. The cloned transporter cDNA predicts a 637 amino acid protein with 12 putative transmembrane domains, exhibiting 44%-45% amino acid sequence identity with other neurotransmitter transporters. These findings have significant implications for the expression of the transporter molecule, the development of diagnostic assays, and the design of therapeutic transporter modulators for clinical treatments.
Career Highlights
Throughout his career, Fremeau has worked with prestigious institutions such as Emory University and Duke University. His research has contributed to a deeper understanding of neurotransmitter transporters and their roles in the brain.
Collaborations
Fremeau has collaborated with esteemed colleagues, including Randy D Blakely and Marc G Caron, further enhancing the impact of his research in the field of neuroscience.
Conclusion
Robert T Fremeau, Jr. is a distinguished inventor whose work has advanced our understanding of neurotransmission and transporter mechanisms in the brain. His innovative patents and collaborations continue to influence research and potential clinical applications in neuroscience.