Robert J Jacob

Title: Innovations and Contributions of Robert J Jacob

Introduction

Robert J Jacob is a notable inventor based in Lexington, KY (US). He has made significant contributions to the field of neuroscience through his innovative research and inventions. With a total of 3 patents, Jacob's work focuses on the interactions between neurotropic viruses and neuronal cells.

Latest Patents

Jacob's latest patents include groundbreaking research on neuronal cell models and methods of use thereof. One of his notable inventions describes a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells. This model allows for inducible virus replication upon forskolin and heat stress treatment. His research further characterizes the model with respect to HSV-2 strain 333, revealing that ND-PC12 cells are non-permissive to HSV-2 replication. The findings indicate that HSV-2 can establish a quiescent infection in ND-PC12 cells, which can be maintained without obligatory anti-viral conditions. This model has appealing features for studying gene expression during the establishment, maintenance, and reactivation phases of the HSV-2 quiescent state in cell culture.

Career Highlights

Jacob is affiliated with the University of Kentucky Research Foundation, where he conducts his research. His work has contributed to a deeper understanding of viral infections in neuronal cells, paving the way for potential therapeutic approaches.

Collaborations

Jacob has collaborated with notable colleagues, including Craig Miller and Robert J Danaher. These collaborations have enhanced the scope and impact of his research in the field.

Conclusion

Robert J Jacob's innovative work in the field of neuroscience and his contributions through his patents highlight the importance of research in understanding viral infections. His findings have significant implications for future studies and potential treatments.