Company Filing History:
Years Active: 2001-2003
Title: Innovations of Robert J. Danaher
Introduction
Robert J. Danaher is an accomplished inventor based in Lexington, KY (US). He has made significant contributions to the field of neuroscience through his innovative research and inventions. With a total of 2 patents, Danaher has focused on developing models that enhance our understanding of viral infections in neuronal cells.
Latest Patents
Danaher’s latest patents include a novel neuronal cell model and methods of use thereof. This invention describes an in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells. The model allows for inducible virus replication upon forskolin and heat stress treatment. Further characterization of the model with respect to HSV-2 strain 333 revealed that ND-PC12 cells are non-permissive to HSV-2 replication. The research also demonstrated that HSV-2 can establish a quiescent infection in ND-PC12 cells, similar to HSV-1, with the transient use of acycloguanosine. Notably, the quiescent state can be maintained in the presence of Vero cell cocultivation, indicating that such cultures are free of infectious virus. A high percentage of quiescently infected PC12 cell cultures can produce HSV-2 in response to forskolin and heat stress treatment for an extended period. These findings highlight the potential of ND-PC12 cells for studying gene expression during the establishment, maintenance, and reactivation phases of the HSV-2 quiescent state in cell culture.
Career Highlights
Danaher is affiliated with the University of Kentucky Research Foundation, where he continues to advance his research in the field of neurobiology. His work has garnered attention for its innovative approach to understanding viral infections in neuronal cells.
Collaborations
Danaher has collaborated with notable colleagues, including Craig Miller and Robert J. Jacob, contributing to a rich environment of research and innovation.
Conclusion
Robert J. Danaher is a prominent inventor whose work in developing neuronal cell models has significant implications for understanding viral infections. His contributions to the field continue to pave the way for future research and innovations.