Company Filing History:
Years Active: 2000
Title: Innovations by Robert G Kuimelis
Introduction
Robert G Kuimelis is an accomplished inventor based in Redwood City, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of novel oligonucleotides for DNA sequencing and nucleic acid amplification. With a total of 2 patents, his work has advanced the methodologies used in genetic research and diagnostics.
Latest Patents
One of his latest patents is titled "Phosphoramidate-phosphodiester oligonucleotide chimera as primers." This invention relates to innovative chimeric phosphoramidate oligonucleotides that possess both N3'-phosphoramidate linkages and phosphodiester linkages. The invention outlines methods for primer extension using these chimeric oligonucleotides in various applications, including PCR and polynucleotide sequencing reactions. The primer extension methods involve annealing a chimeric phosphoramidate oligonucleotide primer to a polynucleotide template, followed by the extension of the primer through a DNA polymerase catalyzed reaction. The invention also includes compositions that enhance the binding affinity of the chimeric oligonucleotides to polynucleotide templates, utilizing divalent cations to stabilize the phosphoramidate linkages against hydrolysis at elevated temperatures.
Career Highlights
Throughout his career, Robert G Kuimelis has worked with notable organizations, including the Perkin-Elmer Corporation. His experience in these companies has allowed him to refine his skills and contribute to groundbreaking research in the field of molecular biology.
Collaborations
Robert has collaborated with several professionals in his field, including Nicole M Ellis and Cheryl R Heiner. These collaborations have fostered a productive environment for innovation and development in biotechnology.
Conclusion
Robert G Kuimelis is a notable inventor whose work in oligonucleotide technology has made a significant impact on genetic research. His innovative patents and collaborations highlight his contributions to the field, paving the way for advancements in DNA sequencing and nucleic acid amplification.