Richard J Colonno

Title: Richard J Colonno: Innovator in Nucleic Acid Research

Introduction

Richard J Colonno is a notable inventor based in Buckingham, PA (US). He has made significant contributions to the field of nucleic acid research, particularly in the development of therapeutic agents for viral infections. With a total of 2 patents, his work has had a substantial impact on medical science.

Latest Patents

Colonno's latest patents include innovations in capped nucleic acid oligomers that inhibit cap-dependent transcription. One of his notable inventions involves novel capped oligonucleotides that are useful in the treatment of influenza infection. This research utilized a synthetically derived 67-nucleotide RNA substrate, which was labeled and analyzed for its interaction with the influenza virus endonuclease activity. The findings revealed that a specific capped 11-nucleotide fragment could prime transcription effectively. Additionally, he has developed combinations of HIV protease inhibitors that effectively inhibit the HIV-1 protease enzyme while minimizing viral cross-resistance, providing new avenues for treating AIDS-related diseases.

Career Highlights

Colonno's career has been marked by his association with Bristol-Myers Squibb Company, where he has contributed to groundbreaking research in virology and pharmacology. His work has been instrumental in advancing therapeutic strategies against viral infections.

Collaborations

Some of his notable coworkers include Thomas D Chung and Christopher W Cianci, who have collaborated with him on various research projects.

Conclusion

Richard J Colonno's innovative work in nucleic acid research and antiviral therapies has positioned him as a key figure in the scientific community. His contributions continue to influence the development of effective treatments for viral infections.