Location History:
- Solana Beach, CA (US) (2004)
- Gaithersburg, MD (US) (2002 - 2005)
Company Filing History:
Years Active: 2002-2005
Title: Innovations of Richard Crowley
Introduction
Richard Crowley is a notable inventor based in Gaithersburg, MD (US). He has made significant contributions to the field of immunology, particularly in the treatment and prevention of immunodeficiency virus infections. With a total of 4 patents to his name, Crowley's work has the potential to impact therapeutic approaches in this critical area of health.
Latest Patents
One of Crowley's latest patents focuses on the treatment and prevention of immunodeficiency virus infection through the administration of non-pyrogenic derivatives of lipid A. This invention highlights the discovery that certain preparations containing lipopolysaccharides (LPS) and lipid A variants exhibit non-pyrogenic properties while demonstrating anti-viral activities. Specifically, these preparations induce β chemokine secretion, such as MIP-1β, without triggering proinflammatory cytokines like TNFα, IL-1β, and IL-6. The findings suggest that these non-pyrogenic preparations can effectively suppress HIV replication in human peripheral blood monocytes, offering a promising therapeutic avenue for combating immunodeficiency virus infections.
Another significant patent involves an adjuvant comprising a lipopolysaccharide antagonist. This invention details LPS preparations isolated from gram-negative bacterial strains that contain mutations in specific genes, such as htrB and msbB. These preparations display both LPS antagonist and adjuvant activities, further contributing to the development of innovative therapeutic methods.
Career Highlights
Richard Crowley is affiliated with the University System of Maryland, where he continues to advance his research and innovations. His work is characterized by a commitment to addressing critical health challenges through scientific inquiry and invention.
Collaborations
Crowley has collaborated with esteemed colleagues, including David M. Hone and George K. Lewis. These partnerships have likely enriched his research endeavors and contributed to the success of his innovative projects.
Conclusion
Richard Crowley's contributions to the field of immunology through his patents and research are noteworthy. His innovative approaches to treating immunodeficiency virus infections demonstrate the potential for significant advancements in therapeutic strategies.