Company Filing History:
Years Active: 1998-2000
Title: Innovations in Malaria Vaccination by Richard C. Hedstrom
Introduction
Richard C. Hedstrom is a notable inventor based in Gaithersburg, MD (US), recognized for his contributions to the field of immunology and vaccine development. He holds 2 patents that focus on innovative approaches to combat malaria, a disease that poses significant health challenges worldwide.
Latest Patents
Hedstrom's latest patents include a polynucleotide vaccine designed to provide protection against malaria. The first embodiment involves a specific plasmid vector, pDIP/PyCSP.1, which incorporates nucleotides encoding targets for specific immune responses. These targets consist of proteins and peptides that elicit protective immune responses against malaria. The second embodiment features a construct that includes nucleotide sequences encoding one or more Plasmodium species proteins within a pharmaceutically acceptable vector. Additionally, a method for controlling malaria in mammals is disclosed, which involves injecting a polynucleotide delivery vector into the host.
Another significant patent focuses on a protective 17 KDA malaria hepatic and erythrocytic stage immunogen. This invention utilizes an IgG1 monoclonal antibody, Navy Yoelii Liver Stage 3 (NYLS3), which effectively recognizes P. yoelii liver stage parasites shortly after they invade mouse hepatocytes. NYLS3 has demonstrated the ability to eliminate up to 98% of liver stage parasites when administered to primary cultures of mouse hepatocytes. Furthermore, intravenous injection of NYLS3 into mice has been shown to delay the onset and reduce the density of blood stage parasitemia following sporozoite or blood stage challenges.
Career Highlights
Hedstrom's work is conducted under the auspices of the United States Navy, where he contributes to advancing medical research and vaccine development. His innovative approaches have the potential to significantly impact malaria treatment and prevention strategies.
Collaborations
Hedstrom has collaborated with esteemed colleagues such as Stephen L. Hoffman and Yupin Charoenvit, further enhancing the research and development of malaria vaccines.
Conclusion
Richard C. Hedstrom's innovative work in malaria vaccination exemplifies the critical role of inventors in addressing global health challenges. His patents reflect a commitment to developing effective solutions for preventing and controlling malaria, showcasing the importance of scientific research in improving public health outcomes.