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Title: Richard A. Friesner: Innovator in Binding Affinity Scoring
Introduction
Richard A. Friesner is a prominent inventor based in New York, NY (US). He has made significant contributions to the field of computational chemistry, particularly in the area of binding affinity scoring. With a total of 8 patents, his work has advanced the understanding of ligand-receptor interactions.
Latest Patents
Friesner's latest patents include innovative methods for scoring binding affinity. One notable patent focuses on binding affinity scoring with a penalty for breaking conjugation between aromatic ligand groups. This method utilizes computer analysis to account for the energy increase when docking disrupts the π-conjugated character of the ligand. It assesses whether the ligand includes a π-conjugated moiety with multiple geometries and imposes a penalty for reduced electron delocalization.
Another significant patent addresses binding affinity scoring functions that penalize compounds making unfavorable hydrophobic contacts with localized water molecules in the receptor active site. This method employs computer-stored data to analyze predicted ligand-receptor structures and assesses penalties for unfavorable interactions with localized water molecules after docking.
Career Highlights
Throughout his career, Richard A. Friesner has worked with esteemed institutions such as Columbia University and Schrodinger, LLC. His expertise in computational methods has positioned him as a leader in the field of molecular modeling and drug design.
Collaborations
Friesner has collaborated with notable individuals in his field, including Robert Murphy and Thomas R. Young. These collaborations have further enriched his research and contributed to the advancement of computational chemistry.
Conclusion
Richard A. Friesner's innovative work in binding affinity scoring has significantly impacted the field of computational chemistry. His contributions continue to influence research and development in drug design and molecular interactions.