Company Filing History:
Years Active: 2001
Title: Reuel Van Atta: Innovator in Double-Stranded Conformational Polymorphism Analysis
Introduction
Reuel Van Atta is a notable inventor based in Mountain View, CA (US). He has made significant contributions to the field of molecular biology through his innovative work on double-stranded conformational polymorphism analysis. His research has implications for genetic analysis and diagnostics.
Latest Patents
Reuel Van Atta holds a patent for a method of double-stranded conformational polymorphism analysis. This method involves combining a probe that includes a cross-linking agent with a sample containing a target sequence. The target sequence may be complementary or have minor mismatches with the probe sequence. After allowing time for hybridization under mild conditions, the hybridized pairs are irradiated to induce cross-link formation. The sample is then analyzed using denaturing gel electrophoresis, where the migration rate is influenced by the degree of complementarity between the probe and the target. In a follow-up experiment, the probe is combined with the sample under high stringency conditions, revealing that cross-linked probe/target formation is significantly lower for mismatched pairs compared to fully matched pairs. This innovative approach enhances the accuracy of genetic analysis.
Career Highlights
Reuel Van Atta is associated with Naxcor, Inc., where he continues to advance his research and development efforts. His work has garnered attention for its potential applications in various fields, including genetics and molecular diagnostics.
Collaborations
Reuel has collaborated with notable colleagues, including Michael L. Wood and David Albagli. These partnerships have contributed to the advancement of his research and the development of innovative methodologies.
Conclusion
Reuel Van Atta's contributions to double-stranded conformational polymorphism analysis exemplify the impact of innovative thinking in the field of molecular biology. His work continues to influence genetic research and diagnostics, showcasing the importance of invention in scientific advancement.