R Michael Blaese

Title: R Michael Blaese: Innovator in Genetic Alteration Detection

Introduction

R Michael Blaese is a notable inventor based in New Hope, PA (US). He has made significant contributions to the field of genetic research, particularly in the detection of rare genetic alterations. His innovative approach has the potential to advance the understanding of genetic modifications in cultured cells.

Latest Patents

R Michael Blaese holds a patent for a method titled "Method for cloning of a rare, specifically mutated cell." This invention focuses on a new technique for detecting a rare product of a directed genetic alteration of a cultured cell. The method is versatile and can be applied to various techniques of making genetic alterations, provided that a pair of closely linked alterations can be achieved. The process involves the sequential use of allele-specific polymerase chain reaction (PCR) to preferentially amplify sequences containing one of the two linked alterations. This is coupled with a secondary method that detects the second change in the PCR product, which can include restriction digestion, traditional sequencing, or pyro-sequencing. Experiments have shown that this method can detect alterations as rare as one correctly altered copy in 10,000 cells.

Career Highlights

R Michael Blaese is currently associated with Pregentis, where he continues to work on innovative solutions in genetic research. His expertise and dedication to advancing the field have made him a valuable asset to his team and the broader scientific community.

Collaborations

R Michael Blaese has collaborated with notable colleagues, including Richard A Metz and Mike DiCola. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.

Conclusion

R Michael Blaese's contributions to the field of genetic alteration detection exemplify the impact of innovative thinking in scientific research. His patented method represents a significant advancement in the ability to detect rare genetic changes, paving the way for future discoveries in genetics.