Peter M Levine

Title: Innovations in Electrochemical Sensing by Peter M. Levine

Introduction

Peter M. Levine is an accomplished inventor based in New York, NY, known for his significant contributions to the field of electrochemical sensing. He holds one patent that showcases his innovative approach to biomolecular detection, which has the potential to revolutionize point-of-care applications.

Latest Patents

Levine's patent, titled "Active CMOS sensor array for electrochemical biomolecular detection," addresses the limitations of traditional fluorescence-based sensing assays. This invention eliminates the need for bulky optical instruments by integrating sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates. The result is a miniaturized sensing platform that enhances portability and enables high-throughput, highly-parallel analysis. One embodiment of this technology includes a four-by-four active sensor array designed for multiplexed electrochemical biomolecular detection using a standard 0.25-μm CMOS process. The integrated potentiostats, control amplifiers, and dual-slope ADCs stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site, which results from biomolecular reactions occurring on the chip surface. The patent also describes post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand harsh electrochemical environments. Demonstrations of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and real-time quantitative and specific DNA hybridization detection.

Career Highlights

Peter M. Levine has made significant strides in the field of electrochemical sensing through his work at Columbia University. His research focuses on developing innovative technologies that enhance the capabilities of biomolecular detection, making it more accessible and efficient for various applications.

Collaborations

Levine has collaborated with notable colleagues, including Kenneth Shepard and Ping Gong, who have contributed to the advancement of his research and innovations in the field.

Conclusion

Peter M. Levine's work in electrochemical sensing exemplifies the potential of innovative technologies to transform biomolecular detection. His contributions are paving the way for more portable and efficient sensing platforms that can significantly impact point-of-care applications.