Peter James Skene

Title: The Innovations of Peter James Skene

Introduction

Peter James Skene is an accomplished inventor based in Issaquah, WA (US). He holds two patents that contribute significantly to the field of genome-wide profiling. His work focuses on innovative methods for detecting chromatin-associated factors, which are crucial for understanding genetic regulation.

Latest Patents

Skene's latest patents include a method for high-efficiency targeted in situ genome-wide profiling. This method involves detecting the binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in a cell. The process includes contacting a permeabilized cell or nucleus with a specific binding agent that recognizes the chromatin-associated factor. This binding agent is linked to a nuclease that is either inactive or an activatable transposome. By activating the nuclease or transposase, the sequence of chromatin DNA bound to the factor is excised. The excised DNA is then isolated, and its sequence is determined, allowing for the detection of the binding event.

Career Highlights

Throughout his career, Skene has worked with notable institutions such as the Fred Hutchinson Cancer Center and the Fred Hutchinson Cancer Research Center. His contributions to these organizations have advanced the understanding of chromatin dynamics and their implications in various biological processes.

Collaborations

Skene has collaborated with esteemed colleagues, including Steven Henikoff and Hatice Seda Kaya Okur. These partnerships have fostered a collaborative environment that enhances research outcomes and innovation.

Conclusion

Peter James Skene's work exemplifies the intersection of innovation and scientific research. His patents and collaborations have made significant strides in the field of genome profiling, contributing to our understanding of genetic mechanisms.