Peter G Foiles

Title: The Innovations of Peter G Foiles

Introduction

Peter G Foiles is a notable inventor based in Croton-on-Hudson, NY (US). He has made significant contributions to the field of immunology, particularly through his innovative work on monoclonal antibodies. His research has implications for understanding DNA damage and its effects on health.

Latest Patents

Peter G Foiles holds a patent for a "Monoclonal antibody-based immunoassay for cyclic DNA adducts resulting." This patent involves the production of monoclonal antibodies specific for the 8R,6R- and 8S,6S-stereoisomers of a specific compound. These cyclic 1,N²-propanodeoxyguanosines are formed in DNA exposed to crotonaldehyde in vitro. The antibodies developed by Foiles demonstrate high specificity, with fifty percent inhibition of binding achievable with just 0.2 picomol of either stereoisomer. Additionally, a high-pressure liquid chromatography-enzyme-linked immunoabsorbent assay was developed, capable of detecting 0.5 μmol of 1,N²-propanodeoxyguanosine per mol of deoxyguanosine. This method was validated through comparison with fluorescence assay results.

Career Highlights

Peter G Foiles is associated with the American Health Foundation, where he has contributed to advancing research in health and disease prevention. His work has been instrumental in developing diagnostic tools that can detect specific DNA adducts, which are crucial for understanding the mechanisms of DNA damage.

Collaborations

Throughout his career, Peter has collaborated with esteemed colleagues such as Stephen S Hecht and Fung-Lung Chung. These collaborations have enriched his research and expanded the impact of his innovations in the field.

Conclusion

Peter G Foiles is a distinguished inventor whose work on monoclonal antibodies has paved the way for advancements in immunoassays and DNA research. His contributions continue to influence the scientific community and enhance our understanding of DNA damage and its implications for health.