Company Filing History:
Years Active: 2024
Title: Innovator Peijin Lv: Advancing Epileptic Drug Synthesis in Zhejiang, China
Introduction
Peijin Lv is an accomplished inventor located in Zhejiang, China. He is recognized for his significant contribution to the field of biochemistry with a focus on the development of a nitrilase mutant that enhances the synthesis of key pharmaceutical intermediates, particularly for anti-epileptic drugs.
Latest Patents
Peijin Lv holds one notable patent, titled "Nitrilase mutant and application thereof in the synthesis of an anti-epileptic drug intermediate." This innovative patent describes a nitrilase mutant protein exhibiting increased thermal stability. The mutation process involves altering one or two of the amino acids at positions 151, 223, and 250 of the amino acid sequence shown in SEQ ID No. 2. Remarkably, the thermal stability of the nitrilase mutant known as AcN-T151V/C223A/C250G has been enhanced by up to 1.73 folds. Notably, this mutant achieved an impressive yield of 95% in synthesizing 1-cyanocyclohexyl acetic acid from 1M 1-cyanocyclohexylacetonitrile at 35°C. Furthermore, when hydrolyzing 1.2M of the same compound, the yield reached up to 97%. His invention also facilitates an 80% yield in synthesizing gabapentin, a widely used anti-epileptic drug.
Career Highlights
Peijin Lv is associated with Zhejiang University, where he continues to innovate and contribute to research in biochemistry and medicinal applications. His work emphasizes improving the efficiency and effectiveness of drug synthesis, showcasing a commitment to advancing pharmaceutical sciences.
Collaborations
Throughout his career, Peijin has collaborated with esteemed colleagues, including Yaping Xue and Neng Xiong. Their joint efforts reflect a strong partnership that enhances the research and development of biochemicals and pharmaceuticals.
Conclusion
Peijin Lv stands out as a remarkable inventor whose work in developing a nitrilase mutant significantly contributes to the field of medicine. His contributions not only advance the synthesis of vital drug intermediates but also showcase the potential for innovation in pharmaceutical research at Zhejiang University. The impacts of his patent will likely resonate within the agricultural and medical fields, paving the way for future advancements in drug synthesis.