Location History:
- Magnolia, TX (US) (1999 - 2000)
- The Woodlands, TX (US) (2000)
Company Filing History:
Years Active: 1999-2000
Title: Paul Hasty: Innovator in DNA Repair Mechanisms
Introduction
Paul Hasty is a notable inventor based in Magnolia, TX (US), recognized for his contributions to the field of molecular biology and genetics. He holds a total of 4 patents, focusing on the disruption of proteins involved in critical DNA repair pathways. His work has significant implications for understanding cell proliferation and viability.
Latest Patents
Hasty's latest patents include groundbreaking research on the mammalian Rad51 protein. One of his inventions details the effects of a mutation, designated rad51.sup.M1, in the mouse MmRAD51 gene. This mutation leads to the death of mutant embryos shortly after implantation. The rad51.sup.M1 cells exhibit hypersensitivity to ionizing radiation, reduced proliferation, programmed cell death, and chromosome loss. His research indicates that disrupting MmRad51 protein interactions can halt cell proliferation and reduce cell viability. Notably, several proteins that interact with MmRad51, such as Brca2 and M96, have been identified. Furthermore, alterations in the N-terminal region of Rad51 can be toxic to cells, emphasizing the importance of this protein in DNA repair mechanisms.
Career Highlights
Throughout his career, Paul Hasty has made significant strides in the field of genetics. He has worked with prominent organizations, including Lexicon Genetics Corporation and the M.D. Anderson Cancer Center. His research has contributed to a deeper understanding of the molecular mechanisms underlying DNA repair and cell survival.
Collaborations
Hasty has collaborated with various professionals in his field, including Dae-sik Lim, to advance research in DNA repair pathways and their implications for therapeutic interventions.
Conclusion
Paul Hasty's innovative work in the field of molecular biology has led to important discoveries regarding DNA repair mechanisms. His patents and research continue to influence the scientific community and hold promise for future therapeutic applications.