Company Filing History:
Years Active: 2003-2005
Title: Paul A Voziyan: Innovator in Protein Folding and Urinary Stone Disease Treatment
Introduction
Paul A Voziyan is a notable inventor based in Overland Park, Kansas. He has made significant contributions to the fields of protein folding and the treatment of urinary stone disease. With a total of 2 patents, his work has the potential to impact both scientific research and clinical practices.
Latest Patents
One of Voziyan's latest patents focuses on chaperonin and osmolyte protein folding and related screening methods. This invention describes an inexpensive in vitro protein folding process aimed at preventing large-scale protein misfolding and aggregation. It allows for the concentration of aggregation-prone chaperonin-protein folding intermediates in a stable, non-aggregating form. The process involves the formation of a chaperone-substrate complex and the release of the substrate using various folding solutions. Notably, when applied to identify and optimize GSΔ468 bacterial glutamine synthetase mutant refolding conditions, this method recovered 67% of the enzymatic activity that was otherwise difficult to achieve with conventional techniques.
Another significant patent by Voziyan provides methods and pharmaceutical compositions for treating or inhibiting urinary stone disease. This invention involves administering pyridoxamine to individuals with urinary stone disease or those at risk, effectively reducing urinary oxalate concentrations.
Career Highlights
Voziyan is affiliated with the University of Kansas Medical Center Research Institute, where he continues to advance his research and innovations. His work is characterized by a commitment to addressing complex biological challenges through innovative solutions.
Collaborations
Throughout his career, Voziyan has collaborated with esteemed colleagues, including Billy G Hudson and Jon Scheimman. These partnerships have further enriched his research endeavors and contributed to the development of his patents.
Conclusion
Paul A Voziyan's contributions to protein folding and urinary stone disease treatment exemplify the impact of innovative research in addressing critical health issues. His patents reflect a dedication to scientific advancement and the potential for real-world applications.