Pau Miau Yuan

Title: The Innovative Contributions of Pau Miau Yuan

Introduction

Pau Miau Yuan is a notable inventor based in San Jose, CA. He has made significant contributions to the field of biochemistry and molecular biology, holding a total of 6 patents. His work primarily focuses on peptide conjugates and fluorescence detection methods, which have important applications in various scientific assays.

Latest Patents

One of his latest patents involves peptide conjugates and fluorescence detection methods for intracellular caspase assays. These polypeptides are labelled with a donor and acceptor pair of dyes, specifically selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye. These peptide conjugates are particularly useful for intracellular and bead-based assays with fluorescence detection. The caspase-recognition site within these conjugates undergoes cleavage, allowing for the detection, location, and quantification of peptide fragments through changes in fluorescence. This intracellular cleavage is correlated with apoptosis, making it a valuable tool in cell biology research.

Another significant patent by Yuan focuses on sulfonated [8,9]benzophenoxazine dyes and their labelled conjugates. These fluorescent dyes are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be utilized in various contexts, including cell surface assays with intact, live cells and nucleic acid detection methods. The new dyes are water-soluble and can be conjugated to a wide range of substrates, such as polynucleotides, nucleosides, nucleotides, peptides, proteins, antibodies, carbohydrates, ligands, particles, and surfaces.

Career Highlights

Throughout his career, Pau Miau Yuan has worked with prominent companies in the biotechnology sector, including Applera Corporation and Applied Biosystems, LLC. His experience in these organizations has contributed to his expertise in developing innovative solutions in the field of molecular biology.

Collaborations

Yuan has collaborated with several notable individuals in his field, including Xiongwei Yan and Sheri Miraglia. These collaborations have further enhanced his research and development efforts, leading to impactful innovations.

Conclusion

Pau Miau Yuan's contributions to the field of biochemistry and molecular biology are significant and impactful. His innovative patents and collaborations reflect his dedication to advancing scientific knowledge and technology. His work continues to influence research and applications in various scientific domains