Company Filing History:
Years Active: 2002-2005
Title: The Innovative Contributions of Patricia Andrade-Grodon
Introduction
Patricia Andrade-Grodon is a notable inventor based in Doylestown, PA (US). She has made significant contributions to the field of molecular biology, particularly in the study of serine proteases. With a total of 6 patents to her name, her work has implications in various medical and scientific domains.
Latest Patents
One of her latest patents involves the molecular identification of a cDNA encoding a novel serine protease termed protease T. This invention describes the deduced amino acid sequence that encodes a prepro form of 290 amino acids. The alignment of this sequence with other well-characterized serine proteases indicates that it belongs to the S1 serine protease family. The expression of protease T mRNA has been found in various tissues, including the stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Additionally, protease T mRNA is present in leukocytes and the Jurkat T cell line, suggesting its potential involvement in various disorders, including gastric, testicular, retinal, dermatological, neurological/neurodegenerative, and immunological conditions. The protease T gene maps to human chromosome 16p13.3, near the tryptase locus, and the enzymatically active protease T generated is suitable for further biochemical analyses.
Career Highlights
Patricia Andrade-Grodon is currently associated with Ortho-McNeil Pharmaceutical Corporation, where she continues her research and development efforts. Her work has been instrumental in advancing the understanding of serine proteases and their applications in medicine.
Collaborations
Throughout her career, she has collaborated with notable colleagues, including Andrew Lawrence Darrow and Jenson Qi. These collaborations have further enriched her research and contributed to her innovative outputs.
Conclusion
Patricia Andrade-Grodon's contributions to the field of molecular biology, particularly through her patents related to serine proteases, highlight her role as a leading inventor. Her work not only advances scientific knowledge but also has the potential to impact various medical fields significantly.